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Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs]

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Item Type:Article
Title:Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs]
Creators Name:Leisegang, M. and Uckert, W.
Abstract:The genetic engineering of T cells with T cell or chimeric antigen receptors generates tumor-specific designer T cells for immunotherapy of cancer. The clinical use of these cells requires (1) careful selection of the target antigen that should be tumor-specific, (2) an optimized configuration of therapeutic genes, to generate T cells of high functional activity and (3) efficient vector systems that allow the generation of sufficient numbers of engineered T cells within a short period of time.
Source:BIOspektrum
ISSN:0947-0867
Publisher:Springer / Spektrum (Germany)
Volume:21
Number:4
Page Range:402-405
Date:June 2015
Official Publication:https://doi.org/10.1007/s12268-015-0594-7

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