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Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

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Item Type:Article
Title:Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin
Creators Name:Kronenberg, G. and Mosienko, V. and Gertz, K. and Alenina, N. and Hellweg, R. and Klempin, F.
Abstract:The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.
Keywords:BDNF, SERT, TPH2, Serotonin, Depression, Antidepressant, Animals, Mice
Source:European Archives of Psychiatry and Clinical Neuroscience
ISSN:0940-1334
Publisher:Springer (Germany)
Volume:266
Number:3
Page Range:281-284
Date:April 2016
Official Publication:https://doi.org/10.1007/s00406-015-0611-3
PubMed:View item in PubMed

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