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New role for the (pro)renin receptor in T cell development

Item Type:Article
Title:New role for the (pro)renin receptor in T cell development
Creators Name:Geisberger, S. and Maschke, U. and Gebhardt, M. and Kleinewietfeld, M. and Manzel, A. and Linker, R.A. and Chidgey, A. and Dechend, R. and Nguyen, G. and Daumke, O. and Muller, D.N. and Wright, M.D. and Binger, K.J.
Abstract:The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterisation of DN T cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, DP and single positive CD4 and CD8. Our study thus identifies a new role for PRR in T cell development.
Keywords:Antigen, T-Cell, alpha-beta Receptors, Cell Differentiation, Cell Surface Receptors, Flow Cytometry, Integrases, T-Lymphocyte Subsets, Thymocytes, Animals, Mice
Source:Blood
ISSN:0006-4971
Publisher:American Society of Hematology (U.S.A.)
Volume:126
Number:4
Page Range:504-507
Date:23 July 2015
Official Publication:https://doi.org/10.1182/blood-2015-03-635292
PubMed:View item in PubMed

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