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| Item Type: | Article |
|---|---|
| Title: | New role for the (pro)renin receptor in T cell development |
| Creators Name: | Geisberger, S., Maschke, U., Gebhardt, M., Kleinewietfeld, M., Manzel, A., Linker, R.A., Chidgey, A., Dechend, R., Nguyen, G., Daumke, O., Muller, D.N., Wright, M.D. and Binger, K.J. |
| Abstract: | The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterisation of DN T cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, DP and single positive CD4 and CD8. Our study thus identifies a new role for PRR in T cell development. |
| Keywords: | Antigen, T-Cell, alpha-beta Receptors, Cell Differentiation, Cell Surface Receptors, Flow Cytometry, Integrases, T-Lymphocyte Subsets, Thymocytes, Animals, Mice |
| Source: | Blood |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Volume: | 126 |
| Number: | 4 |
| Page Range: | 504-507 |
| Date: | 23 July 2015 |
| Additional Information: | Copyright © 2015 by The American Society of Hematology |
| Official Publication: | https://doi.org/10.1182/blood-2015-03-635292 |
| PubMed: | View item in PubMed |
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