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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study

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Item Type:Article
Title:Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study
Creators Name:Morgen, K. and Schneider, M. and Frölich, L. and Tost, H. and Plichta, M.M. and Kölsch, H. and Rakebrandt, F. and Rienhoff, O. and Jessen, F. and Peters, O. and Jahn, H. and Luckhaus, C. and Hüll, M. and Gertz, H.J. and Schröder, J. and Hampel, H. and Teipel, S.J. and Pantel, J. and Heuser, I. and Wiltfang, J. and Rüther, E. and Kornhuber, J. and Maier, W. and Meyer-Lindenberg, A.
Abstract:INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD. METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE epsilon4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network. RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE epsilon4 allele. Lesion distribution was similar among epsilon4 carriers and non-carriers. Only epsilon4 non-carriers showed a correlation between lesion volume and cognitive performance. CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE epsilon4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE epsilon4-mediated risk.
Source:Alzheimer's Research & Therapy
Publisher:BioMed Central
Page Range:27
Date:15 May 2015
Official Publication:https://doi.org/10.1186/s13195-015-0111-8
PubMed:View item in PubMed

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