Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Use of advanced magnetic resonance imaging techniques in neuromyelitis optica spectrum disorder

Item Type:Review
Title:Use of advanced magnetic resonance imaging techniques in neuromyelitis optica spectrum disorder
Creators Name:Kremer, S. and Renard, F. and Achard, S. and Lana-Peixoto, M.A. and Palace, J. and Asgari, N. and Klawiter, E.C. and Tenembaum, S.N. and Banwell, B. and Greenberg, B.M. and Bennett, J.L. and Levy, M. and Villoslada, P. and Saiz, A. and Fujihara, K. and Chan, K.H. and Schippling, S. and Paul, F. and Kim, H.J. and de Seze, J. and Wuerfel, J.T.
Abstract:Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.
Keywords:Clinical Trials as Topic, Diffusion Tensor Imaging, Magnetic Resonance Imaging, Neuromyelitis Optica
Source:JAMA Neurology
ISSN:2168-6149
Publisher:American Medical Association (U.S.A.)
Volume:72
Number:7
Page Range:815-822
Date:July 2015
Official Publication:https://doi.org/10.1001/jamaneurol.2015.0248
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library