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Regional differences in perivascular adipose tissue impacting vascular homeostasis

Item Type:Review
Title:Regional differences in perivascular adipose tissue impacting vascular homeostasis
Creators Name:Gil-Ortega, M. and Somoza, B. and Huang, Y. and Gollasch, M. and Fernández-Alfonso, M.S.
Abstract:Perivascular adipose tissue (PVAT) releases several important vasoactive factors with physiological and pathophysiological paracrine effects. A large body of evidence suggests regional phenotypic and functional differences among PVAT depots, depending on the specific vascular bed or different regions in the vascular bed where the PVAT is located. These non-uniform and separate PVATs exert various paracrine effects on vascular structure and function that largely impact disease states, such as endothelial dysfunction, atherosclerosis, or insulin resistance. This emerging view of PVAT function requires considering heterogeneous PVAT as a specialized organ that can differentially regulate vascular function depending on its anatomical location. In this context, the adipose-vascular axis may represent a novel target for pharmacological intervention in vasculopathy in cardiometabolic disorders.
Keywords:Adipocytes, Adipose Tissue, Cell Differentiation, Homeostasis, Hypertension, Renin-Angiotensin System, Animals
Source:Trends in Endocrinology and Metabolism
ISSN:1043-2760
Publisher:Elsevier (U.S.A.)
Volume:26
Number:7
Page Range:367-375
Date:July 2015
Official Publication:https://doi.org/10.1016/j.tem.2015.04.003
PubMed:View item in PubMed

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