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Identification of a new genomic hot spot of evolutionary diversification of protein function

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Item Type:Article
Title:Identification of a new genomic hot spot of evolutionary diversification of protein function
Creators Name:Winkelmann, A. and You, X. and Gruenewald, N. and Haeussler, U. and Krestel, H. and Haas, C.A. and Schwarz, G. and Chen, W. and Meier, J.C.
Abstract:Establishment of phylogenetic relationships remains a challenging task because it is based on computational analysis of genomic hot spots that display species-specific sequence variations. Here, we identify a species-specific thymine-to-guanine sequence variation in the Glrb gene which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. The resulting splice insert in the receptor for the inhibitory neurotransmitter glycine (GlyR) conveys synaptic receptor clustering and specific association with a particular synaptic plasticity-related splice variant of the postsynaptic scaffold protein gephyrin. This study identifies a new genomic hot spot which contributes to phylogenetic diversification of protein function and advances our understanding of phylogenetic relationships.
Keywords:Alternative Splicing, Amino Acid Sequence, Base Sequence, Biological Evolution, Carrier Proteins, Exons, Gene Expression, Genetic Variation, Genome, Glycine Receptors, Introns, Membrane Proteins, Molecular Sequence Data, Neuronal Plasticity, Neurons, Phylogeny, Species Specificity, Spinal Cord, Synapses, Animals, Galago, Mice
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:10
Number:5
Page Range:e0125413
Date:8 May 2015
Official Publication:https://doi.org/10.1371/journal.pone.0125413
PubMed:View item in PubMed

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