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| Item Type: | Review |
|---|---|
| Title: | Demographic and clinical features of neuromyelitis optica: A review |
| Creators Name: | Pandit, L. and Asgari, N. and Apiwattanakul, M. and Palace, J. and Paul, F. and Leite, M.I. and Kleiter, I. and Chitnis, T. |
| Abstract: | The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it. |
| Keywords: | NMO, Epidemiology, Demographics, Incidence, Prevalence |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 21 |
| Number: | 7 |
| Page Range: | 845-853 |
| Date: | June 2015 |
| Additional Information: | Copyright © The Author(s), 2015. |
| Official Publication: | https://doi.org/10.1177/1352458515572406 |
| PubMed: | View item in PubMed |
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