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Demographic and clinical features of neuromyelitis optica: A review

Item Type:Review
Title:Demographic and clinical features of neuromyelitis optica: A review
Creators Name:Pandit, L. and Asgari, N. and Apiwattanakul, M. and Palace, J. and Paul, F. and Leite, M.I. and Kleiter, I. and Chitnis, T.
Abstract:The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.
Keywords:NMO, Epidemiology, Demographics, Incidence, Prevalence
Source:Multiple Sclerosis Journal
Publisher:Sage Publications
Page Range:845-853
Date:June 2015
Official Publication:https://doi.org/10.1177/1352458515572406
PubMed:View item in PubMed

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