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| Item Type: | Article |
|---|---|
| Title: | Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease |
| Creators Name: | Deák, V.A. and Klussmann, E. |
| Abstract: | A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein kinase A (PKA) by tethering PKA to distinct cellular compartments. Through additional direct protein-protein interactions with PKA substrates and other signaling molecules they form multi-protein complexes. Thereby, AKAPs regulate the access of PKA to its substrates in a temporal and spatial manner as well as the local crosstalk of cAMP/PKA with other signaling pathways. Due to the increasing information on their molecular functioning and three-dimensional structures, and their emerging roles in the development of diseases, AKAPs move into the focus as potential drug targets. In particular, targeting AKAP-dependent protein-protein interactions for interference with local signal processing inside cells potentially allows for the development of therapeutics with high selectivity and fewer side effects. |
| Keywords: | A Kinase Anchor Proteins, Cyclic AMP-Dependent Protein Kinases, Drug Design, Molecular Targeted Therapy, Protein Conformation, Signal Transduction, Animals |
| Source: | Current Drug Targets |
| ISSN: | 1389-4501 |
| Publisher: | Bentham |
| Volume: | 17 |
| Number: | 10 |
| Page Range: | 1147-1171 |
| Date: | 1 August 2016 |
| Official Publication: | https://doi.org/10.2174/1389450116666150416114247 |
| PubMed: | View item in PubMed |
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