Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity

Item Type:	Article
Title:	Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity
Creators Name:	Weygandt, M. and Mai, K. and Dommes, E. and Ritter, K. and Leupelt, V. and Spranger, J. and Haynes, J.D.
Abstract:	A variety of studies suggest that efficient treatments to induce short-term dietary success in obesity exist. However, sustained maintenance of reduced weight is rare as a large proportion of patients start to regain weight when treatment is discontinued. Thus, from a clinical perspective, it would be desirable to identify factors that counteract post-diet weight regain across longer time-scales. To address this question, we extended our previous work on neural impulse control mechanisms of short-term dietary success in obesity and now investigated the mechanisms counteracting long-term weight regain after a diet. Specifically, we measured neural impulse control during a delay discounting task with fMRI at two time points, i.e. the beginning ('T0') and the end ('T12') of a one-year follow-up interval after a 12-week diet. Then, we tested whether activity in the dorsolateral prefrontal cortex (DLPFC) at T0 and whether activity changes across the follow-up period (T0-T12) are linked to success in weight maintenance. The analyses conducted show that control-related DLPFC activity at T0 was coupled to the degree of success in weight maintenance. Consistently, also behavioral measures of control were linked to the degree of success in maintenance. A direct comparison of neural and behavioral control parameters for prognostic weight change modeling revealed that neural signals were more informative. Taken together, neural impulse control in the DLPFC measured with fMRI directly after a diet predicts real-world diet success in obese patients across extended time periods.
Keywords:	DLPFC, Impulse-Control, Impulsivity, Obesity, Weight Maintenance, fMRI
Source:	NeuroImage
ISSN:	1053-8119
Publisher:	Elsevier / Academic Press
Volume:	109
Page Range:	318-327
Date:	1 April 2015
Official Publication:	https://doi.org/10.1016/j.neuroimage.2014.12.073
PubMed:	View item in PubMed

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