In vivo reprogramming for tissue repair

Item Type:	Review
Title:	In vivo reprogramming for tissue repair
Creators Name:	Heinrichs, C. and Spagnoli, F.M. and Berninger, B.
Abstract:	Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic {beta}-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.
Keywords:	Acinar Cells, Brain, Brain Diseases, Cell Differentiation, Cell Lineage, Cell- and Tissue-Based Therapy, Cellular Reprogramming, Insulin-Secreting Cells, Neuroglia, Neurons, Pancreas, Pancreatic Diseases, Regeneration
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	17
Number:	3
Page Range:	204-211
Date:	27 February 2015
Official Publication:	https://doi.org/10.1038/ncb3108
PubMed:	View item in PubMed

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