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In vivo reprogramming for tissue repair

Official URL:https://doi.org/10.1038/ncb3108
PubMed:View item in PubMed
Creators Name:Heinrichs, C. and Spagnoli, F.M. and Berninger, B.
Journal Title:Nature Cell Biology
Journal Abbreviation:Nat Cell Biol
Page Range:204-211
Date:27 February 2015
Keywords:Acinar Cells, Brain, Brain Diseases, Cell Differentiation, Cell Lineage, Cell- and Tissue-Based Therapy, Cellular Reprogramming, Insulin-Secreting Cells, Neuroglia, Neurons, Pancreas, Pancreatic Diseases, Regeneration
Abstract:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic {beta}-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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