Enhanced emotional empathy after mineralocorticoid receptor stimulation in women with borderline personality disorder and healthy women

Item Type:	Article
Title:	Enhanced emotional empathy after mineralocorticoid receptor stimulation in women with borderline personality disorder and healthy women
Creators Name:	Wingenfeld, K. and Kuehl, L.K. and Janke, K. and Hinkelmann, K. and Dziobek, I. and Fleischer, J. and Otte, C. and Roepke, S.
Abstract:	The mineralocorticoid receptor (MR) is highly expressed in the hippocampus and prefrontal cortex. MR have an important role in appraisal processes and in modulating stress-associated emotional reactions but it is not known whether the MR affects empathy. Borderline personality disorder (BPD) is characterized by disturbed emotion regulation and alterations in empathy. In the current study, we examined whether stimulation of the MR enhances empathy in patients with BPD and healthy individuals. In a placebo-controlled study, we randomized 38 women with BPD and without psychotropic medication, and 35 healthy women to either placebo or 0.4 mg fludrocortisone, an MR agonist. Subsequently, all participants underwent two tests of social cognition, the Multifaceted Empathy Test (MET) and the Movie for the Assessment of Social Cognition (MASC), measuring cognitive and emotional facets of empathy. Eighteen BPD patients and 18 healthy women received placebo, whereas 20 BPD patients and 17 healthy women received fludrocortisone. In the MET, fludrocortisone enhanced emotional empathy across groups, whereas cognitive empathy was not affected. In the MASC, no effect of fludrocortisone could be revealed. In both tests, BPD patients and healthy women did not differ significantly in cognitive and emotional empathy and in their response to fludrocortisone. Stimulation of MR enhanced emotional empathy in healthy women and in BPD patients. Whether fludrocortisone might have a therapeutic role in psychotherapeutic processes, remains to be elucidated.
Keywords:	Borderline Personality Disorder, Cognition, Emotions, Empathy, Fludrocortisone, Mineralocorticoid Receptors
Source:	Neuropsychopharmacology
ISSN:	0893-133X
Publisher:	Nature Publishing Group
Volume:	39
Number:	8
Page Range:	1799-1804
Date:	July 2014
Official Publication:	https://doi.org/10.1038/npp.2014.36
PubMed:	View item in PubMed

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