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Neurodegeneration in multiple sclerosis: novel treatment strategies

Item Type:Review
Title:Neurodegeneration in multiple sclerosis: novel treatment strategies
Creators Name:Luessi, F. and Siffrin, V. and Zipp, F.
Abstract:In recent years it has become clear that the neuronal compartment already plays an important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course of chronic neuroinflammation is a key factor in determining long-term disability in patients. Viewing MS as both inflammatory and neurodegenerative has major implications for therapy, with CNS protection and repair needed in addition to controlling inflammation. Here, the authors' review recently elucidated molecular insights into inflammatory neuronal/axonal pathology in MS and discuss the resulting options regarding neuroprotective and regenerative treatment strategies.
Keywords:Multiple Sclerosis, Neurodegeneration, Neuronal Injury, Neuroprotection, Treatment, Animals
Source:Expert Review of Neurotherapeutics
ISSN:1473-7175
Publisher:Expert Reviews (U.K.)
Volume:12
Number:9
Page Range:1061-1077
Date:September 2012
Official Publication:https://doi.org/10.1586/ern.12.59
PubMed:View item in PubMed

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