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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Item Type:Article
Title:Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Abstract:Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Keywords:Chromosome Mapping, European Continental Ancestry Group, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Multiple Sclerosis, Single Nucleotide Polymorphism
Source:Nature Genetics
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Volume:45
Number:11
Page Range:1353-1360
Date:November 2013
Additional Information:Volker Siffrin is a member of the International Multiple Sclerosis Genetics Consortium (IMSGC).
Official Publication:https://doi.org/10.1038/ng.2770
PubMed:View item in PubMed

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