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Vitamin D depletion aggravates hypertension and target-organ damage

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Item Type:Article
Title:Vitamin D depletion aggravates hypertension and target-organ damage
Creators Name:Andersen, L.B. and Przybyl, L. and Haase, N. and von Versen-Höynck, F. and Qadri, F. and Jørgensen, J.S. and Sorensen, G.L. and Fruekilde, P. and Poglitsch, M. and Szijártó, I. and Gollasch, M. and Peters, J. and Muller, D.N. and Christesen, H.T. and Dechend, R.
Abstract:BACKGROUND: We tested the controversial hypothesis that vitamin D depletion aggravates hypertension and target-organ damage by influencing renin. METHODS AND RESULTS: Four-week-old double-transgenic rats (dTGR) with excess angiotensin (Ang) II production due to overexpression of the human renin (hREN) and angiotensinogen (hAGT) genes received vitamin D-depleted (n=18) or standard chow (n=15) for 3 weeks. The depleted group had very low serum 25-hydroxyvitamin D levels (mean+/-SEM; 3.8+/-0.29 versus 40.6+/-1.19 nmol/L) and had higher mean systolic BP at week 5 (158+/-3.5 versus 134.6+/-3.7 mm Hg, P<0.001), week 6 (176.6+/-3.3 versus 162.3+/-3.8 mm Hg, P<0.01), and week 7 (171.6+/-5.1 versus 155.9+/-4.3 mm Hg, P<0.05). Vitamin D depletion led to increased relative heart weights and increased serum creatinine concentrations. Furthermore, the mRNAs of natriuretic peptides, neutrophil gelatinase-associated lipocalin, hREN, and rRen were increased by vitamin D depletion. Regulatory T cells in the spleen and in the circulation were not affected. Ang metabolites, including Ang II and the counter-regulatory breakdown product Ang 1 to 7, were significantly up-regulated in the vitamin D-depleted groups, while ACE-1 and ACE-2 activities were not affected. CONCLUSIONS: Short-term severe vitamin D depletion aggravated hypertension and target-organ damage in dTGR. Our data suggest that even short-term severe vitamin D deficiency may directly promote hypertension and impacts on renin-angiotensin system components that could contribute to target-organ damage. The findings add to the evidence that vitamin D deficiency could also affect human hypertension.
Keywords:Hypertension, Renin, Vitamin D, Animals, Rats
Source:Journal of the American Heart Association
Page Range:e001417
Date:February 2015
Official Publication:https://doi.org/10.1161/JAHA.114.001417
PubMed:View item in PubMed

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