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Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach

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Item Type:Article
Title:Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach
Creators Name:Grosenick, D. and Cantow, K. and Arakelyan, K. and Wabnitz, H. and Flemming, B. and Skalweit, A. and Ladwig, M. and Macdonald, R. and Niendorf, T. and Seeliger, E.
Abstract:We hypothesize that combining quantitative near-infrared spectroscopy (NIRS) with established invasive techniques will enable advanced insights into renal hemodynamics and oxygenation in small animal models. We developed a NIRS technique to monitor absolute values of oxygenated and deoxygenated hemoglobin and of oxygen saturation of hemoglobin within the renal cortex of rats. This NIRS technique was combined with invasive methods to simultaneously record renal tissue oxygen tension and perfusion. The results of test procedures including occlusions of the aorta or the renal vein, hyperoxia, hypoxia, and hypercapnia demonstrated that the combined approach, by providing different but complementary information, enables a more comprehensive characterization of renal hemodynamics and oxygenation.
Source:Biomedical Optics Express
ISSN:2156-7085
Publisher:Optical Society of America
Volume:6
Number:2
Page Range:309-323
Date:1 February 2015
Official Publication:https://doi.org/10.1364/BOE.6.000309
PubMed:View item in PubMed

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