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ASICs and mammalian mechanoreceptor function

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Item Type:Review
Title:ASICs and mammalian mechanoreceptor function
Creators Name:Omerbašić, D. and Schuhmacher, L.N. and Bernal Sierra, Y.A. and Smith, E.S.J. and Lewin, G.R.
Abstract:It is well established that some members of the Deg/ENaC super family of amiloride sensitive ion channels can participate directly in the transduction of mechanical stimuli by sensory neurons in invertebrates. A large body of work has also implicated the acid sensing ion channels family (ASIC1-4) as participants in regulating mechanoreceptor sensitivity in vertebrates. In this review we provide an overview of the physiological and genetic evidence for involvement of ASICs in mechanosensory function. On balance, the available evidence favors the idea that these channels have an important regulatory role in mechanosensory function. It is striking how diverse the consequences of Asic gene deletion are on mechanosensory function with both gain and loss of function effects being observed depending on sensory neuron type. We conclude that other, as yet unknown, molecular partners of ASIC proteins may be decisive in determining their precise physiological role in mechanosensory neurons.
Keywords:Mechanotransduction, ASICs, Ion Channels, Mechanoreceptor, Nociceptor, Touch, Potassium Channels, Animals
Source:Neuropharmacology
ISSN:0028-3908
Publisher:Elsevier / Pergamon (U.K.)
Volume:94
Page Range:80-86
Date:July 2015
Official Publication:https://doi.org/10.1016/j.neuropharm.2014.12.007
PubMed:View item in PubMed

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