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Competition between target sites of regulators shapes post-transcriptional gene regulation

Official URL:https://doi.org/10.1038/nrg3853
PubMed:View item in PubMed
Creators Name:Jens, M. and Rajewsky, N.
Journal Title:Nature Reviews Genetics
Journal Abbreviation:Nat Rev Genet
Page Range:113-126
Date:February 2015
Keywords:Biological Models, Competitive Binding, Genetic Epigenesis, Messenger RNA, MicroRNAs, RNA Interference, Transcriptome
Abstract:Post-transcriptional gene regulation (PTGR) of mRNA turnover, localization and translation is mediated by microRNAs (miRNAs) and RNA-binding proteins (RBPs). These regulators exert their effects by binding to specific sequences within their target mRNAs. Increasing evidence suggests that competition for binding is a fundamental principle of PTGR. Not only can miRNAs be sequestered and neutralized by the targets with which they interact through a process termed 'sponging', but competition between binding sites on different RNAs may also lead to regulatory crosstalk between transcripts. Here, we quantitatively model competition effects under physiological conditions and review the role of endogenous sponges for PTGR in light of the key features that emerge.
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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