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Sodium chloride, SGK1, and Th17 activation

Item Type:Review
Title:Sodium chloride, SGK1, and Th17 activation
Creators Name:Binger, K.J. and Linker, R.A. and Muller, D.N. and Kleinewietfeld, M.
Abstract:The incidence of autoimmune diseases in Western civilizations is increasing rapidly, suggesting an influence of environmental factors, such as diet. The pathogenesis of several of these autoimmune diseases is characterized by aberrant activation of T helper 17 (Th17) cells. Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1). In this review, we summarize the recently disclosed mechanisms by which salt has been shown to affect SGK1 and, subsequently, Th17 activation.
Keywords:Salt, SGK1, T Cells, Autoimmunity, Animals
Source:Pfluegers Archiv European Journal of Physiology
ISSN:0031-6768
Publisher:Springer (Germany)
Volume:467
Number:3
Page Range:543-550
Date:March 2015
Official Publication:https://doi.org/10.1007/s00424-014-1659-z
PubMed:View item in PubMed

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