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An atlas of combinatorial transcriptional regulation in mouse and man

Item Type:Article
Title:An atlas of combinatorial transcriptional regulation in mouse and man
Creators Name:Ravasi, T. and Suzuki, H. and Cannistraci, C.V. and Katayama, S. and Bajic, V.B. and Tan, K. and Akalin, A. and Schmeier, S. and Kanamori-Katayama, M. and Bertin, N. and Carninci, P. and Daub, C.O. and Forrest, A.R.R. and Gough, J. and Grimmond, S. and Han, J.H. and Hashimoto, T. and Hide, W. and Hofmann, O. and Kamburov, A. and Kaur, M. and Kawaji, H. and Kubosaki, A. and Lassmann, T. and van Nimwegen, E. and MacPherson, C.R. and Ogawa, C. and Radovanovic, A. and Schwartz, A. and Teasdale, R.D. and Tegner, J. and Lenhard, B. and Teichmann, S.A. and Arakawa, T. and Ninomiya, N. and Murakami, K. and Tagami, M. and Fukuda, S. and Imamura, K. and Kai, C. and Ishihara, R. and Kitazume, Y. and Kawai, J. and Hume, D.A. and Ideker, T. and Hayashizaki, Y.
Abstract:Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
Keywords:Cell Differentiation, Gene Expression Regulation, Gene Regulatory Networks, Molecular Evolution, Monocytes, Organ Specificity, Smad3 Protein, Trans-Activators, Transcription Factors, Animals, Mice
Publisher:Cell Press
Page Range:744-752
Date:5 March 2010
Official Publication:https://doi.org/10.1016/j.cell.2010.01.044
PubMed:View item in PubMed

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