Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue

Item Type:	Article
Title:	Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue
Creators Name:	Finke, C. and Schlichting, J. and Papazoglou, S. and Scheel, M. and Freing, A. and Soemmer, C. and Pech, L.M. and Pajkert, A. and Pfueller, C.J. and Wuerfel, J.T. and Ploner, C. and Paul, F. and Brandt, A.U.
Abstract:	BACKGROUND: Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis, but its pathophysiological mechanisms are poorly understood. It is in particular unclear whether and how fatigue relates to structural and functional brain changes. OBJECTIVE: We aimed to analyse the association of fatigue severity with basal ganglia functional connectivity, basal ganglia volumes, white matter integrity and grey matter density. METHODS: In 44 patients with relapsing-remitting multiple sclerosis and 20 age- and gender-matched healthy controls, resting-state fMRI, diffusion tensor imaging and voxel-based morphometry was performed. RESULTS: In comparison with healthy controls, patients showed alteration of grey matter density, white matter integrity, basal ganglia volumes and basal ganglia functional connectivity. No association of fatigue severity with grey matter density, white matter integrity and basal ganglia volumes was observed within patients. In contrast, fatigue severity was negatively correlated with functional connectivity of basal ganglia nuclei with medial prefrontal cortex, precuneus and posterior cingulate cortex in patients. Furthermore, fatigue severity was positively correlated with functional connectivity between caudate nucleus and motor cortex. CONCLUSION: Fatigue is associated with distinct alterations of basal ganglia functional connectivity independent of overall disability. The pattern of connectivity changes suggests that disruption of motor and non-motor basal ganglia functions, including motivation and reward processing, contributes to fatigue pathophysiology in multiple sclerosis.
Keywords:	Multiple Sclerosis, Fatigue, Basal Ganglia, Reward System, Functional Neuroimaging, Diffusion Tensor Imaging, Voxel-Based Morphometry
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	21
Number:	7
Page Range:	925-934
Date:	June 2015
Official Publication:	https://doi.org/10.1177/1352458514555784
PubMed:	View item in PubMed

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