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Drep-2 is a novel synaptic protein important for learning and memory

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Item Type:Article
Title:Drep-2 is a novel synaptic protein important for learning and memory
Creators Name:Andlauer, T.F.M. and Scholz-Kornehl, S. and Tian, R. and Kirchner, M. and Babikir, H.A. and Depner, H. and Loll, B. and Quentin, C. and Gupta, V.K. and Holt, M.G. and Dipt, S. and Cressy, M. and Wahl, M.C. and Fiala, A. and Selbach, M. and Schwärzel, M. and Sigrist, S.J.
Abstract:CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.
Keywords:CIDE-N Protein Family, Fragile X Syndrome, Learning and Memory, Metabotropic Glutamate Receptors, Mushroom Body, Neuroscience, Synapses, Animals, Drosophila melanogaster
Publisher:eLife Sciences Publications
Page Range:e03895
Date:13 November 2014
Official Publication:https://doi.org/10.7554/eLife.03895
PubMed:View item in PubMed

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