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Oxidative status imbalance in patients with metabolic syndrome: Role of the myeloperoxidase/hydrogen peroxide axis

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Item Type:Article
Title:Oxidative status imbalance in patients with metabolic syndrome: Role of the myeloperoxidase/hydrogen peroxide axis
Creators Name:Da Fonseca, L.J.S. and Nunes-Souza, V. and Guedes, G.D.S. and Schettino-Silva, G. and Mota-Gomes, M.A. and Rabelo, L.A.
Abstract:The present study evaluated the cardiometabolic and redox balance profiles in patients with Metabolic Syndrome compared to apparently healthy individuals, and the participation of the myeloperoxidase/hydrogen peroxide axis in systemic lipid peroxidation. Twenty-four patients with Metabolic Syndrome and eighteen controls underwent a full clinical assessment. Venous blood samples were collected for general biochemical dosages, as well as for the oxidative stress analyses (superoxide dismutase, catalase, and arginase activities; and lipid peroxidation, myeloperoxidase activity, nitrite, and hydrogen peroxide concentrations in plasma). Arterial stiffness was assessed by radial artery applanation tonometry. Plasma lipid peroxidation, erythrocyte superoxide dismutase activity, myeloperoxidase activity, and hydrogen peroxide concentrations were shown to be increased in Metabolic Syndrome patients, without significant differences for the other enzymes, plasma nitrite concentrations, and arterial stiffness. Linear regression analysis revealed a positive and significant correlation between lipid peroxidation and myeloperoxidase and also between this enzyme and hydrogen peroxide. In contrast, such correlation was not observed between lipid peroxidation and hydrogen peroxide. In summary, Metabolic Syndrome patients exhibited evident systemic redox imbalance compared to controls, with the possible participation of the myeloperoxidase/hydrogen peroxide axis as a contributor in lipid peroxidation.
Keywords:Case-Control Studies, Hydrogen Peroxide, Lipid Peroxidation, Metabolic Syndrome X, Oxidative Stress, Peroxidase
Source:Oxidative Medicine and Cellular Longevity
ISSN:1942-0900
Publisher:Hindawi (U.S.A.)
Volume:2014
Page Range:898501
Date:2014
Official Publication:https://doi.org/10.1155/2014/898501
PubMed:View item in PubMed

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