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Gibbon genome and the fast karyotype evolution of small apes

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Item Type:Article
Title:Gibbon genome and the fast karyotype evolution of small apes
Creators Name:Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvak, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Abstract:Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ~5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
Keywords:Genetic Selection, Genetic Transcription Termination, Genome, Hominidae, Hylobates, Karyotype, Molecular Evolution, Molecular Sequence Data, Phylogeny, Retroelements, Animals
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:513
Number:7517
Page Range:195-201
Date:11 September 2014
Official Publication:https://doi.org/10.1038/nature13679
PubMed:View item in PubMed

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