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Mixed messages: re-initiation factors regulate translation of animal mRNAs

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Official URL:https://doi.org/10.1038/cr.2014.114
PubMed:View item in PubMed
Creators Name:Obermayer, B. and Rajewsky, N.
Journal Title:Cell Research
Journal Abbreviation:Cell Res
Volume:24
Number:12
Page Range:1383-1384
Date:December 2014
Keywords:Drosophila Proteins, Eukaryotic Initiation Factors, Gene Expression Regulation, Protein Biosynthesis, Animals, Drosophila
Abstract:When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.
ISSN:1001-0602
Publisher:Nature Publishing Group (U.K.)
Item Type:Editorial

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