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Preparation for hypertension specialists : genomics reveals the pathogenesis of hypertension

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Item Type:Editorial
Title:Preparation for hypertension specialists : genomics reveals the pathogenesis of hypertension
Creators Name:Luft, F.C.
Abstract:Genomics is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes, the complete set of DNA within a single cell of an organism. Research into the genetics of hypertension has now expanded to genomics. Two approaches have dominated this field. One relies on large populations in which the phenotype, hypertension versus no hypertension, or hypertension-relevant phenotypes are compared. Genome-wide association (GWAS) analyses of (>1 million) common variants identify relevant loci and possible genes exerting small effects. Detailed studies on APOL1 and SH2B3 are opening entire new fields of research. Family-based Mendelian studies have identified rare variants that exert very large effects on blood pressure. Mechanistically these studies have been a bonanza of new information. The approaches are complementary.
Keywords:Hypertension, Cardiovascular Disease, Genetics, Mendelian, Genome-Wide Association Studies (GWAS)
Source:Journal of the American Society of Hypertension
ISSN:1933-1711
Publisher:Elsevier (The Netherlands)
Volume:8
Number:8
Page Range:607-611
Date:August 2014
Official Publication:https://doi.org/10.1016/j.jash.2014.07.004
PubMed:View item in PubMed

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