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Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: Immune targets in demyelinating neuropathies?

Item Type:Article
Title:Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: Immune targets in demyelinating neuropathies?
Creators Name:Miyaji, K. and Paul, F. and Shahrizaila, N. and Umapathi, T. and Yuki, N.
Abstract:Given their localization and important role in regulating complement, complement regulatory proteins may act as target antigens and their antibodies as biomarkers in demyelinating neuropathies. We investigated the binding of autoantibodies to complement regulatory proteins (CD46, 55 and 59) in demyelinating diseases. In 42 acute inflammatory demyelinating polyneuropathy, 23 chronic inflammatory demyelinating polyneuropathy, 13 acute motor axonal neuropathy, 71 multiple sclerosis, and 19 neuromyelitis optica patients as well as 55 healthy controls, we were unable to detect significant titers of antibodies to CD46, CD55 and CD59. These autoantibodies are unlikely to be biomarkers in acute and chronic inflammatory demyelinating polyneuropathies.
Keywords:Acute Inflammatory Demyelinating Polyneuropathy, Chronic Inflammatory Demyelinating Polyneuropathy, Complement Regulatory Protein, Multiple Sclerosis
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:276
Number:1-2
Page Range:172-174
Date:November 2014
Official Publication:https://doi.org/10.1016/j.jneuroim.2014.08.004
PubMed:View item in PubMed

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