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Detailing intra-lesional venous lumen shrinking in multiple sclerosis investigated by sFLAIR MRI at 7-T

Item Type:Editorial
Title:Detailing intra-lesional venous lumen shrinking in multiple sclerosis investigated by sFLAIR MRI at 7-T
Creators Name:Mueller, K. and Kuchling, J. and Doerr, J. and Harms, L. and Ruprecht, K. and Niendorf, T. and Wuerfel, J. and Paul, F. and Sinnecker, T.
Abstract:Intra-lesional venous lumen shrinking detectable by MRI was suggested as an in vivo marker of inflammation in multiple sclerosis (MS). In our study mean diameters of pre-, post- and intra-lesional venous sections were determined in 49 patients with MS or clinically isolated syndrome (CIS) using a pixel-wise analysis on susceptibility-weighted fluid-attenuated inversion recovery (sFLAIR) images and T2*-weighted (T2*w) imaging at 7 Tesla (T). We observed post-to-intra-lesional venous lumen shrinking on T2*w images (p = 0.036) in an analysis of 338 venous sections. Pre-to-intra-lesional venous lumen reduction was only detectable in less than 50 % of lesions and failed statistical significance when analysing T2*w (p = 0.325) and sFLAIR images (p = 0.258). In conclusion, thinning of intra-lesional veins in MS is-if detectable at all-probably less severe than previously reported, and affects only a minority of MS lesions.
Keywords:Multiple Sclerosis, Magnetic Resonance Imaging, Central Vein, Perivenous, Intra-Lesional Venous Lumen Shrinking, Perivascular
Source:Journal of Neurology
ISSN:0340-5354
Publisher:Springer (Germany)
Volume:261
Number:10
Page Range:2032-2036
Date:October 2014
Official Publication:https://doi.org/10.1007/s00415-014-7460-2
PubMed:View item in PubMed

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