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Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

Item Type:Article
Title:Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria
Creators Name:Schippling, S. and Balk, L. and Costello, F. and Albrecht, P. and Balcer, L. and Calabresi, P. and Frederiksen, J. and Frohman, E. and Green, A. and Klistorner, A. and Outteryck, O. and Paul, F. and Plant, G. and Traber, G. and Vermersch, P. and Villoslada, P. and Wolf, S. and Petzold, A.
Abstract:BACKGROUND: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. OBJECTIVE: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place. RESULTS: The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed. CONCLUSION: Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.
Keywords:Atrophy, Multiple Sclerosis, Outcome Measurement, Progressive
Source:Multiple Sclerosis Journal
ISSN:1352-4585
Publisher:Sage Publications (U.K.)
Volume:21
Number:2
Page Range:163-170
Date:February 2015
Official Publication:https://doi.org/10.1177/1352458514538110
PubMed:View item in PubMed

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