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Presynaptic mechanisms of neuronal plasticity and their role in epilepsy

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Item Type:Review
Title:Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
Creators Name:Meier, J.C. and Semtner, M. and Winkelmann, A. and Wolfart, J.
Abstract:Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of selected presynaptic mechanisms to epilepsy including voltage- and ligand-gated ion channels as well as cannabinoid and adenosine receptor signaling.
Keywords:Epilepsy, Axon, RNA Editing, Potassium Channels, Glycine Receptor, Homeostatic Regulation, Neuropsychiatric Disorders, Hippocampus
Source:Frontiers in Cellular Neuroscience
ISSN:1662-5102
Publisher:Frontiers Research Foundation (Switzerland)
Volume:8
Page Range:164
Date:17 June 2014
Additional Information:Erratum in: Front Cell Neurosci 8: 206.
Official Publication:https://doi.org/10.3389/fncel.2014.00164
PubMed:View item in PubMed

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