Polymerization, bending, tension: What happens at the leading edge of motile cells?

Item Type:	Article
Title:	Polymerization, bending, tension: What happens at the leading edge of motile cells?
Creators Name:	Falcke, M. and Zimmermann, J.
Abstract:	The forces experienced by filaments in actin based propulsion in reconstituted systems and cell motility, the mechanical properties of the lamellipodium of motile cells due to filament branching and cross-linking, the free filament contour length between branch points, the mechanisms of the force-velocity relation and velocity oscillations are all topics of ongoing debate. Here, we review results with a modelling concept considering the F-actin network as weakly cross-linked in a region with dynamic depth close to the propelled obstacle and gel-like further back. It offers quantitative explanations for steady motion and oscillation mechanisms in reconstituted systems and motile cells, and the force-velocity relation of fish keratocytes.
Keywords:	Branched Actin Networks, Force-Velocity Relation, Retrograde Flow, Migrating Cells, Arp2/3 Complex, Cross-Linking, Lamellipodial Protrusion, Cytoskeletal Dynamics, Electron Tomography, Lipid Vesicles
Source:	European Physical Journal - Special Topics
ISSN:	1951-6355
Publisher:	Springer
Volume:	223
Number:	7
Page Range:	1353-1372
Date:	June 2014
Additional Information:	Authors' reply in: Eur Phys J Spec Top 223(7): 1433-1435.
Official Publication:	https://doi.org/10.1140/epjst/e2014-02195-9

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