Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Item Type:	Article
Title:	Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
Creators Name:	Tsilidis, K.K. and Allen, N.E. and Appleby, P.N. and Rohrmann, S. and Nöthlings, U. and Arriola, L. and Gunter, M.J. and Chajes, V. and Rinaldi, S. and Romieu, I. and Murphy, N. and Riboli, E. and Tzoulaki, I. and Kaaks, R. and Lukanova, A. and Boeing, H. and Pischon, T. and Dahm, C.C. and Overvad, K. and Quirós, J.R. and Fonseca-Nunes, A. and Molina-Montes, E. and Gavrila Chervase, D. and Ardanaz, E. and Khaw, K.T. and Wareham, N.J. and Roswall, N. and Tjønneland, A. and Lagiou, P. and Trichopoulos, D. and Trichopoulou, A. and Palli, D. and Pala, V. and Tumino, R. and Vineis, P. and Bueno-de-Mesquita, H.B. and Malm, J. and Orho-Melander, M. and Johansson, M. and Stattin, P. and Travis, R.C. and Key, T.J.
Abstract:	The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC). Among 139,131 eligible men, 4,531 were diagnosed with prostate cancer over an average follow-up of 12 years. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by EPIC-participating center and age at recruitment, and adjusted for education, smoking status, body mass index, waist circumference, and physical activity. In a subset of men without prostate cancer, the cross-sectional association between circulating concentrations of androgens and insulin-like growth factor proteins with diabetes status was also investigated using linear regression models. Compared to men with no diabetes, men with diabetes had a 26% lower risk of prostate cancer (HR, 0.74; 95% CI, 0.63 - 0.86). There was no evidence that the association differed by stage (P-heterogeneity, 0.19) or grade (P-heterogeneity, 0.48) of the disease, although the numbers were small in some disease subgroups. In a subset of 626 men with hormone measurements, circulating concentrations of androstenedione, total testosterone and insulin-like growth factor binding protein-three were lower in men with diabetes compared to men without diabetes. This large European study has confirmed an inverse association between self-reported diabetes mellitus and subsequent risk of prostate cancer.
Keywords:	Type 2 Diabetes, Prostate Cancer, Cohort Study, Androgens, Insulin-Like Growth Factor Proteins
Source:	International Journal of Cancer
ISSN:	0020-7136
Publisher:	Wiley-Blackwell
Volume:	136
Number:	2
Page Range:	372-381
Date:	15 January 2015
Official Publication:	https://doi.org/10.1002/ijc.28989
PubMed:	View item in PubMed

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