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RNA interference in mice

Item Type:Review
Title:RNA interference in mice
Creators Name:Kuehn, R. and Streif, S. and Wurst, W.
Abstract:Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach. This review provides an overview of the progress of RNAi in vivo, with emphasis on systemic/local siRNA delivery, viral shRNA vectors, shRNA vector transgenic mice and conditional systems to control shRNA vectors. Taken together, the data from 80 in vivo studies show that RNAi is a useful tool that offers new opportunities for functional genomics in mice.
Keywords:RNAi, Mouse, Functional Genomics, Transgenic Mice, siRNA, Animals, Mice
Source:Handbook of Experimental Pharmacology
Series Name:Handbook of Experimental Pharmacology
Title of Book:Conditional mutagenesis: an approach to disease models
ISSN:0171-2004
ISBN:978-3-540-35108-5
Publisher:Springer (Germany)
Volume:178
Number:1
Page Range:149-176
Number of Pages:149
Date:2007
Official Publication:https://doi.org/10.1007/978-3-540-35109-2_7
PubMed:View item in PubMed

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