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| Item Type: | Review |
|---|---|
| Title: | RNA interference in mice |
| Creators Name: | Kühn, R. and Streif, S. and Wurst, W. |
| Abstract: | Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach. This review provides an overview of the progress of RNAi in vivo, with emphasis on systemic/local siRNA delivery, viral shRNA vectors, shRNA vector transgenic mice and conditional systems to control shRNA vectors. Taken together, the data from 80 in vivo studies show that RNAi is a useful tool that offers new opportunities for functional genomics in mice. |
| Keywords: | RNAi, Mouse, Functional Genomics, Transgenic Mice, siRNA, Animals, Mice |
| Source: | Handbook of Experimental Pharmacology |
| Series Name: | Handbook of Experimental Pharmacology |
| Title of Book: | Conditional mutagenesis: an approach to disease models |
| ISSN: | 0171-2004 |
| ISBN: | 978-3-540-35108-5 |
| Publisher: | Springer |
| Volume: | 178 |
| Number: | 1 |
| Page Range: | 149-176 |
| Number of Pages: | 149 |
| Date: | 2007 |
| Official Publication: | https://doi.org/10.1007/978-3-540-35109-2_7 |
| PubMed: | View item in PubMed |
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