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Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

Item Type:Comment
Title:Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4
Creators Name:Sadlack, B. and Kuehn, R. and Schorle, H. and Rajewsky, K. and Mueller, W. and Horak, I.
Abstract:Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice.
Keywords:Interleukin-2, Interleukin-4, Development and Proliferation of Lymphocytes, Cytokines, Animals, Knock-Out Mice, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:24
Number:1
Page Range:281-284
Date:January 1994
Official Publication:https://doi.org/10.1002/eji.1830240144
PubMed:View item in PubMed

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