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Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Item Type:Article
Title:Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants
Creators Name:Texidó, G. and Jacobs, H. and Meiering, M. and Kühn, R. and Roes, J. and Müller, W. and Gilfillan, S. and Fujiwara, H. and Kikutani, H. and Yoshida, N. and Amakawa, R. and Benoist, C. and Mathis, D. and Kishimoto, T. and Mak, T.W. and Rajewsky, K.
Abstract:We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.
Keywords:Hypermutation, Terminal Deoxynucleotidyl Transferase, CD23, Interleukin-4, IgD, Animals, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:26
Number:8
Page Range:1966-1969
Date:August 1996
Official Publication:https://doi.org/10.1002/eji.1830260843
PubMed:View item in PubMed

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