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Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia

Item Type:Article
Title:Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia
Creators Name:Mueller, W. and Kuehn, R. and Rajewsky, K.
Abstract:The murine interleukin 4 (IL4)-encoding cDNA expressed under the control of the immunoglobulin heavy chain enhancer/promoter was inserted into the mouse germ line. All B cells present in the IL4 transgenic mice show a marked increase in expression of class II histocompatibility (Ia) antigens compared to B cells from control mice. In vivo 5-bromo-2'-deoxyuridine incorporation and cell cycle analysis revealed no significant increase in B cell proliferation in spleens of IL4 transgenic mice compared to littermate controls. Likewise, serum immunoglobulin concentrations in IL4 transgenic mice were not increased. From these experiments we conclude that Ia hyperexpression on B cells per se does not induce activation of autoreactive T cells leading to B cell proliferation or hypergammaglobulinemia.
Keywords:B-Lymphocytes, Histocompatibility Antigens Class II, Hypergammaglobulinemia, Immunoglobulin Isotypes, Interleukin-4, Lymphocyte Activation, Animals, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:21
Number:4
Page Range:921-925
Date:April 1991
Official Publication:https://doi.org/10.1002/eji.1830210410
PubMed:View item in PubMed

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