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Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury

Item Type:Article
Title:Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury
Creators Name:Enge, M. and Wilhelmsson, U. and Abramsson, A. and Stakeberg, J. and Kuehn, R. and Betsholtz, C. and Pekny, M.
Abstract:Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this has led to the speculation that PDGF-B may have a role in CNS development, in maintenance, or in response to CNS injury. To test these hypotheses, we developed mice in which PDGF-B was ablated genetically in postmitotic neurons at sites where PDGF-B is normally expressed. We found that these mice develop to adulthood without apparent defects. We demonstrate PDGF-B expression in the postnatal mouse hippocampus and forebrain cortex. We show that neuron-specific knockout of PDGF-B does not influence the astroglial and angiogenic responses to injury in the hippocampus or forebrain cortex. We conclude that the role of neuron-derived PDGF-B remains obscure. A role for neuron-derived PDGF-B, if existing, might be redundant with other CNS growth factors. Alternatively, other and more specific analyses of CNS functions in the normal and injured states will be required to demonstrate such a role.
Keywords:PDGF, Gene Targeting, Brain Injury, Reactive Astrocytes, Angiogenic Response, Pericyte Recruitment, Animals, Mice
Source:Neurochemical Research
ISSN:0364-3190
Publisher:Kluwer Academic Publ. (U.S.A.)
Volume:28
Number:2
Page Range:271-279
Date:February 2003
Official Publication:https://doi.org/10.1023/A:1022421001288
PubMed:View item in PubMed

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