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Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study

Item Type:Article
Title:Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study
Creators Name:Kuchling, J. and Ramien, C. and Bozin, I. and Dörr, J. and Harms, L. and Rosche, B. and Niendorf, T. and Paul, F. and Sinnecker, T. and Wuerfel, J.
Abstract:Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.
Keywords:MRI, Primary Progressive Multiple Sclerosis, PPMS, Relapsing-Remitting Multiple Sclerosis, RRMS, Ultrahigh Field MRI, 7 T MRI
Source:Multiple Sclerosis Journal
ISSN:1352-4585
Publisher:Sage Publications (U.K.)
Volume:20
Number:14
Page Range:1866-1871
Date:December 2014
Official Publication:https://doi.org/10.1177/1352458514531084
PubMed:View item in PubMed

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