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The Ebf1 knockout mouse and glomerular maturation

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Item Type:Editorial
Title:The Ebf1 knockout mouse and glomerular maturation
Creators Name:Schmidt-Ott, K.M.
Abstract:Mice deficient in the transcription factor early B-cell factor 1 (Ebf1) lack mature B lymphocytes but have additional phenotypes suggesting functions outside the hematopoietic system. Fretz et al. report that these mice also exhibit quantitative and qualitative developmental renal defects and develop progressive podocyte foot process effacement. The findings not only suggest that Ebf1 may be pivotal to the transcriptional podocyte network, but also illustrate the importance of distinguishing cell-autonomous and non-autonomous inputs to podocyte maturation and integrity.
Keywords:Kidney Glomerulus, Trans-Activators, Animals
Source:Kidney International
ISSN:0085-2538
Publisher:Nature Publishing Group (U.S.A.)
Volume:85
Number:5
Page Range:1014-1016
Date:May 2014
Official Publication:https://doi.org/10.1038/ki.2013.472
PubMed:View item in PubMed

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