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High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS

Item Type:Article
Title:High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS
Creators Name:Tuerkmen, S. and Binder, A. and Gerlach, A. and Niehage, S. and Melissari, M.T. and Inandiklioglu, N. and Doerken, B. and Burmeister, T.
Abstract:Multiple myeloma (MM) is a malignant B-cell neoplasm characterized by an uncontrolled proliferation of aberrant plasma cells in the bone marrow. Chromosome aberrations in MM are complex and represent a hallmark of the disease, involving many chromosomes that are altered both numerically and structurally. Nearly half of the cases are nonhyperdiploid and show IGH translocations with the following partner genes: CCND1, FGFR3 and MMSET, MAF, MAFB, and CCND3. The remaining 50% are grouped into a hyperdiploid group that is characterized by multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. In this study, we analyzed the immunoglobulin light chain kappa (IGK, 2p12) and lambda (IGL, 22q11) loci in 150 cases, mostly with MM but in a few cases monoclonal gammopathy of undetermined significance (MGUS), without IGH translocations. We identified aberrations in 27% (= 40 patients) including rearrangements (12%), gains (12%), and deletions (4.6%). In 6 of 18 patients with IGK or/and IGL rearrangements, we detected a MYC rearrangement which suggests that MYC is the translocation partner in the majority of these cases.
Keywords:Chromosome Aberrations, Immunoglobulin kappa-Chains, Immunoglobulin lambda-Chains, Fluorescence In Situ Hybridization, Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma
Source:Genes Chromosomes & Cancer
ISSN:1045-2257
Publisher:Wiley-Blackwell (U.S.A.)
Volume:53
Number:8
Page Range:650-656
Date:August 2014
Official Publication:https://doi.org/10.1002/gcc.22175
PubMed:View item in PubMed

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