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NF-κB in cellular senescence and cancer treatment

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Item Type:Review
Title:NF-κB in cellular senescence and cancer treatment
Creators Name:Jing, H. and Lee, S.
Abstract:The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we emphasize the connection of NF-κB with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-{kappa}B produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.
Keywords:Cancer, Chemotherapy, NF-{kappa}B, Senescence, Animals
Source:Molecules and Cells
Publisher:Springer (Singapore)
Page Range:189-195
Date:31 March 2014
Official Publication:https://doi.org/10.14348/molcells.2014.2353
PubMed:View item in PubMed

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