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| Item Type: | Review |
|---|---|
| Title: | NF-κB in cellular senescence and cancer treatment |
| Creators Name: | Jing, H. and Lee, S. |
| Abstract: | The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we emphasize the connection of NF-κB with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-{kappa}B produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example. |
| Keywords: | Cancer, Chemotherapy, NF-{kappa}B, Senescence, Animals |
| Source: | Molecules and Cells |
| ISSN: | 1016-8478 |
| Publisher: | Springer |
| Volume: | 37 |
| Number: | 3 |
| Page Range: | 189-195 |
| Date: | 31 March 2014 |
| Official Publication: | https://doi.org/10.14348/molcells.2014.2353 |
| PubMed: | View item in PubMed |
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