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NF-κB in cellular senescence and cancer treatment

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Item Type:Review
Title:NF-κB in cellular senescence and cancer treatment
Creators Name:Jing, H. and Lee, S.
Abstract:The NF-{kappa}B pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-{kappa}B in cancer cells, recent findings postulate that NF-{kappa}B participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-{kappa}B. In this review, we discuss implications of the NF-{kappa}B signaling pathway in cancer. Particularly, we emphasize the connection of NF-{kappa}B with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-{kappa}B produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.
Keywords:Cancer, Chemotherapy, NF-{kappa}B, Senescence, Animals
Source:Molecules and Cells
ISSN:1016-8478
Publisher:Springer (Singapore)
Volume:37
Number:3
Page Range:189-195
Date:31 March 2014
Official Publication:https://doi.org/10.14348/molcells.2014.2353
PubMed:View item in PubMed

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