NF-κB in cellular senescence and cancer treatment

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Item Type:	Review
Title:	NF-κB in cellular senescence and cancer treatment
Creators Name:	Jing, H. and Lee, S.
Abstract:	The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we emphasize the connection of NF-κB with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-{kappa}B produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.
Keywords:	Cancer, Chemotherapy, NF-{kappa}B, Senescence, Animals
Source:	Molecules and Cells
ISSN:	1016-8478
Publisher:	Springer
Volume:	37
Number:	3
Page Range:	189-195
Date:	31 March 2014
Official Publication:	https://doi.org/10.14348/molcells.2014.2353
PubMed:	View item in PubMed

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