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Soluble fms-like tyrosine kinase-1 and atherosclerosis in chronic kidney disease

Item Type:Editorial
Title:Soluble fms-like tyrosine kinase-1 and atherosclerosis in chronic kidney disease
Creators Name:Luft, F.C.
Abstract:Vascular endothelial growth factor (VEGF) and its cousins, such as placental growth factor, have moved into the daily clinical arena. One-step-removed regulators, such as the VEGF splice variant soluble fms-like tyrosine kinase-1 (sFlt-1), now clinically emerge. sFlt-1 keeps our corneas 'clean.' However, sFlt-1 could also cause disease, such as preeclampsia. The report by Matsui et al. on ApoE and sFlt-1 gene-deleted mice could foster important subsequent research. We are limited only by our imaginations.
Keywords:Atherosclerosis, Chronic Renal Insufficiency, Vascular Endothelial Growth Factor Receptor-1, Animals
Source:Kidney International
ISSN:0085-2538
Publisher:Nature Publishing Group (U.S.A.)
Volume:85
Number:2
Page Range:238-240
Date:February 2014
Official Publication:https://doi.org/10.1038/ki.2013.402
PubMed:View item in PubMed

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