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Gene expression: degrade to derepress

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Official URL:https://doi.org/10.1002/embj.201387752
PubMed:View item in PubMed
Creators Name:McShane, E. and Selbach, M.
Journal Title:EMBO Journal
Journal Abbreviation:EMBO J
Volume:33
Number:5
Page Range:407-408
Date:3 March 2014
Keywords:Cyclic AMP Response Element-Binding Protein, Gene Expression Regulation, Nuclear Receptor Co-Repressor 1, Proteolysis, Transcriptional Regulatory Elements, Animals
Abstract:Chromatin immunoprecipitation and sequencing (ChIP‐seq) provides a static snap‐shot of DNA‐associated proteins which fails to reflect the dynamics of the DNA‐bound proteome. Now, Catic and co‐workers combine ubiquitin ChIP‐seq and proteasome inhibitors to map sites of DNA‐associated protein degradation on a genome‐wide scale. They identify an ubiquitin ligase which targets a transcriptional repressor for destruction by the proteasome, thus activating transcription of specific genes. These findings reveal that the ubiquitin proteasome system actively regulates transcription.
ISSN:0261-4189
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Editorial

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