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Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women

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Item Type:Article
Title:Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women
Creators Name:Nimptsch, K. and Malik, V.S. and Fung, T.T. and Pischon, T. and Hu, F.B. and Willett, W.C. and Fuchs, C.S. and Ogino, S. and Chan, A.T. and Giovannucci, E. and Wu, K.
Abstract:Adolescent diet may be etiologically relevant for later risk of colorectal adenoma, a precursor of colorectal cancer. We aimed to examine associations between adolescent dietary patterns (derived using factor analysis) and risk of colorectal adenoma in middle adulthood. We analyzed data from 17,221 women participating in the Nurses' Health Study II, who had completed a validated high school (HS) food frequency questionnaire in 1998 when they were 34-51 years old, and had subsequently undergone at least one lower bowel endoscopy. Between 1998 and 2007, 1,299 women were diagnosed with at least one colorectal adenoma. In multivariable models adjusted for adult dietary patterns, a higher "prudent" pattern during HS, characterized by high consumption of vegetables, fruit and fish was associated with a statistically significantly lower risk of rectal (odds ratio [OR] highest vs. lowest quintile, 0.45, 95% CI 0.27-0.75, p-trend=0.005), but not colon adenomas. A higher "Western" pattern during HS, characterized by high consumption of desserts and sweets, snack foods and red and processed meat, was significantly associated with rectal (OR 1.78, 95% CI 1.12-2.85, p-trend=0.005) and advanced (OR 1.58, 95% CI 1.07-2.33, p-trend=0.08), but not associated with colon or non-advanced adenomas. This study suggests that overall eating patterns during high school may influence later risk of rectal and advanced adenoma, independent of adult diet. Our results support the hypothesis that diet during early life may influence colorectal carcinogenesis.
Keywords:Adolescent Diet, Dietary Pattern, Colorectal Adenoma
Source:International Journal of Cancer
ISSN:0020-7136
Publisher:Wiley (U.S.A.)
Volume:134
Number:10
Page Range:2458-2467
Date:15 May 2014
Official Publication:https://doi.org/10.1002/ijc.28578
PubMed:View item in PubMed

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