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The IκB kinase complex in NF-κB regulation and beyond

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Item Type:Review
Title:The IκB kinase complex in NF-κB regulation and beyond
Creators Name:Hinz, M. and Scheidereit, C.
Abstract:The I{kappa}B kinase (IKK) complex is the signal integration hub for NF-{kappa}B activation. Composed of two serine-threonine kinases (IKK{alpha} and IKK{beta}) and the regulatory subunit NEMO (also known as IKK{gamma}), the IKK complex integrates signals from all NF-{kappa}B activating stimuli to catalyze the phosphorylation of various I{kappa}B and NF-{kappa}B proteins, as well as of other substrates. Since the discovery of the IKK complex components about 15 years ago, tremendous progress has been made in the understanding of the IKK architecture and its integration into signaling networks. In addition to the control of NF-{kappa}B, IKK subunits mediate the crosstalk with other pathways, thereby extending the complexity of their biological function. This review summarizes recent advances in IKK biology and focuses on emerging aspects of IKK structure, regulation and function.
Keywords:Cancer, Development, Differentiation, Inflammation, Immunity, Animals
Source:EMBO Reports
ISSN:1469-221X
Publisher:Nature Publishing Group (U.K.)
Volume:15
Number:1
Page Range:46-61
Date:1 January 2014
Official Publication:https://doi.org/10.1002/embr.201337983
PubMed:View item in PubMed

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