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Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease

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Item Type:Article
Title:Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease
Creators Name:Wittenbecher, F. and Rieger, K. and Dziubianau, M. and Herholz, A. and Mensen, A. and Blau, I.W. and Uharek, L. and Dörken, B. and Thiel, A. and Na, I.K.
Abstract:Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD.
Keywords:HSCT, Antithymocyte Globulin, CD8 T Cell, Effector Memory, Naive
Source:Leukemia Research Reports
ISSN:2213-0489
Publisher:Elsevier (The Netherlands)
Volume:2
Number:2
Page Range:82-85
Date:27 September 2013
Official Publication:https://doi.org/10.1016/j.lrr.2013.09.001
PubMed:View item in PubMed

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