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Role of "western diet" in inflammatory autoimmune diseases

Item Type:Review
Title:Role of "western diet" in inflammatory autoimmune diseases
Creators Name:Manzel, A. and Muller, D.N. and Hafler, D.A. and Erdman, S.E. and Linker, R.A. and Kleinewietfeld, M.
Abstract:Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the "Western diet", including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and 'fast foods', promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of "Western diet" with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.
Keywords:Western Diet, Autoimmune Diseases, Autoimmunity, Obesity, Sodium, Inflammatory, Gut Microbiome, T Cell Regulation, Animals
Source:Current Allergy and Asthma Reports
Publisher:Current Medicine Group
Page Range:404
Date:January 2014
Official Publication:https://doi.org/10.1007/s11882-013-0404-6
PubMed:View item in PubMed

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