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OCT4 and the acquisition of oocyte developmental competence during folliculogenesis

Item Type:Article
Title:OCT4 and the acquisition of oocyte developmental competence during folliculogenesis
Creators Name:Zuccotti, M. and Merico, V. and Belli, M. and Mulas, F. and Sacchi, L. and Zupan, B. and Redi, C.A. and Prigione, A. and Adjaye, J. and Bellazzi, R. and Garagna, S.
Abstract:The role that the transcription factor OCT4 plays during oocyte growth is yet unknown. In this review, we summarise the data on its potential role in the acquisition of oocyte developmental competence in the mouse. These studies describe the presence in MII oocytes and 2-cell embryos of an OCT4 transcriptional network that might be part of the molecular signature of maternal origin on which the inner cell mass and the embryonic stem cell-associated pluripotency is assembled and shaped. The Oct4-gene regulatory network thus provides a connection between eggs, early preimplantation embryos and embryonic stem cells.
Keywords:OCT4, Oocyte, Developmental Competence, Preimplantation Development, Pluripotency, Animals, Mice
Source:International Journal of Developmental Biology
ISSN:0214-6282
Publisher:UBC Press (Spain)
Volume:56
Number:10-12
Page Range:853-858
Date:2012
Official Publication:https://doi.org/10.1387/ijdb.120174mz
PubMed:View item in PubMed

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